Harikrushna Machines Private Limited

Pharmaceutical Ampoule Sealing Machine/ Ampoule Filling & Sealing Machine for filling and sealing glass ampoules for pharmaceutical, veterinary, and biotech industries. Our Multi-axis servo-driven ampoule filling and sealing machine has a servo system driving feed worm, infeed starwheels, ampoule travelling rack, syringes, nozzles diving system, and ampoule cutting system. The ampoule-filling mechanism is executed by imported Rotary Syringes.
Model: HMPL-AFSOutput Speed: Up to 400 ampoules per minute
Key Features

• Minimum Quantity of Ampoule at Infeed Wire Mesh Conveyor Machine Stop with Auto Restart Facilities.
• Machine Suitable For 1 ML To 25 ML Ampoule (with Help of Change Parts).
• Fitted with change parts of 2 ML/3 ML Ampoule.
• No Ampoule No Filling System in Individual Syringe.
• Peristaltic Pump attached with Servo Motor (8 Nos. = 1 Set) suitable for 1 ML to 25 ML Fill.
• A.C. Variable Drive For Main Machine and Conveyor.
• Rotomotive/Bonfiglioli Make Gear Box.
• Nitrogen Pre and Post Purging System with Rota Meter.
• Delta Make PLC Unit with Delta Make 10.2” Color Touch Screen HMI with Printing Facilities.
• Exhaust Duct with Blower (Exhaust Duct from The Machine to The Service Floor will be in Customer Scope).
• SS-304 Construction.
• Servo Motor-based Label Applicator.
• Sensor- Sick/Baumer/Benner Make
• Gear Box – Rotomotive/Bonfiglioli
• Fitted with change parts for 2/3 ML Ampoule
• In Built A.C. Frequency Drive For Speed Control
• Output: 300 Ampoule/minute On Base Of 2/3 ML Ampoule
• Change Parts of each size of Ampoule
• Infeed Feed Worm -1 No.
• Star Wheel Bracket -3 Nos. with 1 No. Guide Set
• Travelling Rack -1 No.
• Peristaltic Pump Synchronized Attached with Servo Motor
• Optional Accessories
• LAF Unit Suitable for Amp. Filling & Sealing Machine
• Toughen Glass Cabinet with SS Structure

Machine Brief

• Laminar Air Flow Unit For Ampoule Filling Sealing Machine
• Infeed Worm – 1 Nos.
• Star Wheel Bracket -3 Nos. with 1 Nos. Guide Set
• Travelling Rack-1 Nos.
• Discharging Hopper

OptionalToughen Glass Cabinet with SS Pipe Structure

The Automatic Ampoule Filling Sealing Machine by Harikrushna Machines Pvt. Ltd. (HMPL) ensures precise, sterile, and high-speed filling and sealing for glass ampoules used in pharmaceutical, veterinary, and biotech applications. Equipped with a Laminar Air Flow (LAF) System, the machine maintains a contamination-free environment throughout the process. Its multi-axis servo-driven technology controls the feed worm, infeed starwheels, ampoule travel rack, syringe dosing, nozzle diving, and ampoule cutting system, delivering unmatched accuracy and repeatability. Using imported rotary syringes, the system provides smooth, consistent filling and perfectly formed seals at speeds of up to 400 ampoules per minute, making it an ideal solution for modern high-efficiency sterile manufacturing lines.

The Automatic Vial Filling Machine and Rubber Bunging Machine consist of a main structure covered with SS cabinet safety acrylic cover, laminar air flow, in-feed turntable Machine, peristaltic pump filling Machine, Delrin Slate conveyor, outfeed turn table, vibrator bowl & chute for rubber stopper, pneumatic components and electrical panel, AC Drive, PLC & HMI.

Sterilizing Depyrogenation Tunnel, also known as dry heat sterilization tunnel or hot air tunnel, is specialized equipment used in the pharmaceutical and biotechnology industries to remove pyrogens from vials, ampoules, and other containers used in the manufacturing of sterile products.

Sterilization and Depyrogenation Tunnel by Harikrushna Machines Pvt. Ltd. (HMPL Sterile)Harikrushna Machines (HMPL Sterile) offers state-of-art Pharmaceutical Sterilization & Depyrogenation Tunnel for drying, sterilization & depyrogenation of glass containers such as ampoules, vials, injection and infusion bottles, cartridges or syringes.

Key Features and Principles:High Temperature:Controlled Airflow:Conveyor System:Validation:Monitoring and Control:Materials Compatibility:
Tunnel for drying, sterilization and depyrogenationHarikrushna Machines Pvt. Ltd. (HMPL Sterile) offers a diverse array of sterilization tunnels, delivering versatile solutions for the efficient and sustainable treatment of various glass container types. Utilizing dry heat sterilization enables you to attain consistent treatment quality while optimizing energy consumption. Whether you are packaging liquid pharmaceuticals into ampoules, vials, injection and infusion bottles, cartridges, or syringes, ensuring the dependable sterilization of containers plays a crucial role in enhancing product safety.

Vial Sterilization Tunnel:A vial sterilization tunnel is a specialized piece of equipment used in pharmaceutical manufacturing.It ensure the sterility of vials before they are filled with drugs or other sterile substances.This tunnel employs a controlled environment, typically utilizing dry heat or other sterilization methods.To eliminate or reduce microbial contaminants, ensuring the integrity and safety of the final pharmaceutical product.

Depyrogenation Tunnels | Sterilization Tunnels Manufacturer and Exporter in IndiaDepyrogenation tunnels, also known as dry heat sterilization tunnels or hot air tunnels, are specialized equipment used in the pharmaceutical and biotechnology industries to remove pyrogens from vials, ampoules, and other containers used in the manufacturing of sterile products.

Sterilization and Depyrogenation Tunnel by Harikrushna Machines Pvt. Ltd. (HMPL Sterile)Harikrushna Machines (HMPL Sterile) offers state-of-art Pharmaceutical Sterilization & Depyrogenation Tunnel for drying, sterilization & depyrogenation of glass containers such as ampoules, vials, injection and infusion bottles, cartridges or syringes.

Key Features and Principles:High Temperature:Controlled Airflow:Conveyor System:Validation:Monitoring and Control:Materials Compatibility:
Tunnel for drying, sterilization and depyrogenationHarikrushna Machines Pvt. Ltd. (HMPL Sterile) offers a diverse array of sterilization tunnels, delivering versatile solutions for the efficient and sustainable treatment of various glass container types. Utilizing dry heat sterilization enables you to attain consistent treatment quality while optimizing energy consumption. Whether you are packaging liquid pharmaceuticals into ampoules, vials, injection and infusion bottles, cartridges, or syringes, ensuring the dependable sterilization of containers plays a crucial role in enhancing product safety.

Vial Sterilization Tunnel:A vial sterilization tunnel is a specialized piece of equipment used in pharmaceutical manufacturing.It ensure the sterility of vials before they are filled with drugs or other sterile substances.This tunnel employs a controlled environment, typically utilizing dry heat or other sterilization methods.To eliminate or reduce microbial contaminants, ensuring the integrity and safety of the final pharmaceutical product.

Vial Capping Machine consists of the main structure covered with SS cabinet safety polycarbonate glass doors, Delrin slate conveyor, vials height adjustment screw, centralized lubrication system, out-feed turntable, vibrator bowl & chute for cap, in-feed screw & star plate, sensors, electrical panel, AC Drive, PLC & HMI.

• Model: HMPL-PRE-RVS
• Output Speed: 30 to 120 Vials/Minute

Key Features:

• The machine is manufactured or developed accordance with GMP standards.
• The structure is made of MS and cladded with SS 304.
• Rigid vibration free construction for trouble free performance.
• The mechanical driven system of the whole machine is through foot mounted motor and gear box.
• The complete synchronized mechanism is designed on gears and chain.
• Totally synchronized PLC controlled system.
• The whole machine covered with cabinet of SS and polycarbonate glass doors.
• User friendly to adjust the different speed (vials/minute) with the help of HMI.
• The Real output speed (vials/minute) appear on HMI.
• Few change parts are required for different vials.
• Vials without bungs and no caps are detected by the sensors and give the alarm alert and machine stop itself.
• Daily production ratio, production counter is given with the password protection.
• There is a special designed vibrator bowl and chute with no cap sensors for continuous flow of the cap.
• The faults such as vials without bungs, no caps appear on the HMI and can be attended easily.
• Very less mechanical adjustment required due to the special design.
• PLC modes are user friendly and can be operated easily.
• User-friendly and very less maintenance required.
• The structure construction of machine is useful to mount laminar flow.
• Most reliable and proven components such as Festo/SMC make pneumatic and electrical/electronic such as Bonfiglioli/Motovario/Rotomotive make AC motor, Delta make Drives, Delta make PLC & HMI, LEUZE/BANNER/SICK make Sensors, MCB & relay “CE” certified.

The Pre Filled Syringes Machine by Harikrushna Machines Pvt. Ltd. Is a comprehensive solution for packaging pre-filled syringes and dental cartridges. This advanced system begins with the Pre-Filled Syringe Loading System, which ensures efficient handling of syringes. The Automatic Nest Picking-Up and Transferring System facilitates seamless movement for filling and sealing operations. An integrated Sensor inspection system meticulously checks for shortages or empty rubber stoppers, ensuring only complete and correctly filled syringes proceed. The Rubber Stopper Feeding System automates the placement of stoppers, while the Finger Grips Loading System enhances usability. Precision is guaranteed with the Plunger Rod Insertion and Tightening mechanism, which rotates to lock and fix the plunger rod with controlled tightness, ensuring reliable and secure packaging. This line embodies efficiency and accuracy, delivering high-quality, ready-to-use pre-filled syringes and dental cartridges.
Pre-Filled Syringe Loading SystemThe Pre-Filled Syringe Loading System is a crucial component in the pre-filled syringe packaging process, offering efficient and reliable handling of syringes. Designed with precision and versatility, this system ensures seamless integration into packaging lines, enabling swift and accurate loading of pre-filled syringes. Its advanced features streamline the production process, minimizing downtime and maximizing productivity. With user-friendly controls and robust construction, the Pre-Filled Syringe Loading System enhances operational efficiency, contributing to the seamless packaging of pharmaceutical products with consistent quality and reliability.
Sensor Inspecting System for Reject Shortage or Empty Rubber Stopper LineThe Sensor Inspecting System for Reject Shortage or Empty Rubber Stopper Line is a critical component ensuring the integrity and quality of pre-filled syringe packaging. Employing advanced sensor technology, this system meticulously inspects each syringe for shortages or empty rubber stoppers, swiftly identifying any anomalies that could compromise product safety or efficacy. By promptly detecting and rejecting defective syringes, this system upholds stringent quality standards. Its reliable performance enhances efficiency in the packaging process.
Rubber Stopper Feeding SystemThe Rubber Stopper Feeding System is a vital component in the pre-filled syringe packaging process, ensuring the seamless and efficient placement of rubber stoppers. Engineered with precision and reliability in mind, this system automates the feeding of rubber stoppers into the packaging line maximizing productivity. Its advanced design enables consistent and accurate positioning of stoppers, contributing to the integrity and quality of the final packaged product. With user-friendly controls and robust construction, the Rubber Stopper Feeding System enhances operational efficiency, ensuring smooth and uninterrupted packaging of pre-filled syringes while maintaining stringent quality standards.

The Vial Liquid Packaging Line by Harikrushna Machines Pvt. Ltd. is a state-of-the-art solution designed for precision, speed, and reliability. Tailored for vial sizes ranging from 2 ml to 10 ml, this line achieves an impressive output speed of up to 400 vials per minute, making it ideal for high-volume production environments. It is meticulously engineered to handle free-flowing liquids, ensuring consistent and accurate filling while maintaining aseptic packaging standards to meet the stringent demands of the pharmaceutical industry.
This comprehensive Injectable Vial Liquid Filling Line includes an Automatic Rotary Vial Washing Machine or Linear Vial Washing Machine, Sterilization and Depyrogenation Tunnel, Automatic Injectable Liquid Filling and Rubber Stoppering Machine with LAF (Laminar Air Flow), and Automatic Vial Aluminum/Flip-Off Capping Machine. Additional features, such as an Online Visual Inspection Conveyor, Automatic Vial Sticker Labeling Machine with 21 CFR compliance, and Automatic Vial Cartoning Machine, streamline operations and enhance overall efficiency. Designed with flexibility in mind, the system can be customized to meet unique customer requirements, ensuring seamless integration into existing production workflows.
With its emphasis on accuracy, aseptic compliance, versatility, and high-speed performance, the Vial Liquid Packaging Line sets a benchmark for pharmaceutical manufacturing. Whether for filling, capping, labeling, or cartoning, this robust solution delivers exceptional results while ensuring product integrity and safety at every stage of the packaging process.

Harikrushna Machines Pvt. Ltd. introduces the Eye Drop Filling And Capping Machine/ Automatic Monoblock Liquid Filling, Inner Plugging, and Screw Capping Machine, a versatile and innovative solution for seamless pharmaceutical packaging. Designed to integrate three critical processes—liquid filling, inner plugging, and capping—this machine enhances productivity and accuracy while meeting the demands of modern pharmaceutical manufacturing. With a remarkable output speed of up to 200 bottles per minute, it is ideal for packaging liquid bottles, eye and ear drop bottles, vials, and nasal sprays, ensuring precision and compliance with GMP standards.

Built with advanced technology and a robust SS 316L and SS 304 structure, the Monoblock Filling Machine guarantees a vibration-free operation and exceptional durability. Its cutting-edge features, including a rotary motion filling system, electromagnetic vibrators, and co-eccentric nozzles, deliver precise and efficient filling. The machine’s 7” touchscreen HMI with PLC programming ensures user-friendly operation, offering real-time fault detection and easy changeovers. Additionally, features like the nitrogen purging option, CIP/SIP-compatible pharma-grade silicon tubes, and LAF-equipped clean-air environment highlight its focus on quality and hygiene.

As an ISO 9001:2015 and CE-certified manufacturer, Harikrushna Machines Pvt. Ltd. ensures superior engineering and exceptional after-sales support. Whether you are a start-up or a large-scale business, this Monoblock Filling Machine is your trusted partner in achieving consistent results, reduced downtime, and streamlined operations. Its versatility and customizable options make it the perfect choice for businesses aiming to elevate their packaging efficiency.

The Vial Powder Filling Machine by Harikrushna Machines Pvt. Ltd. (HMPL) exemplifies cutting-edge innovation for aseptic powder filling and rubber stoppering. Designed with a sturdy mechanical drive system, this advanced machine ensures uninterrupted operation during long production hours. Its precise vacuum and air pressure-based powder wheel allow for consistent filling, while the roller-based self-picking rubber stoppering system guarantees secure vial closure. Whether filling micro-dose sterile powders or accommodating varying vial sizes from 5 ml to 30 ml, this machine delivers unmatched performance and reliability.
A hallmark of engineering excellence, the machine boasts advanced features such as a servo-operated powder wheel, dual powder hoppers with individual gear motors, and "No Vial, No Fill" and "No Stopper, No Fill" safety mechanisms. With an impressive output speed of up to 400 vials per minute, the system seamlessly adapts to customer-specific requirements. Its precision ensures ±2% filling accuracy, even under controlled humidity, making it ideal for pharmaceutical production lines. Constructed with high-grade SS 316L contact parts, the machine prioritizes aseptic conditions and ease of maintenance, including autoclaving compatibility.
Integrated with a Delta PLC unit and a user-friendly 10” touchscreen HMI, this machine offers intuitive control over all critical operations, including variable speed adjustments and accurate weight settings. Its robust construction, featuring SS 304 pipe structures and Delrin star wheels, enhances durability and efficiency. With HMPL’s expertise spanning from 1st generation mechanical machines to 4th generation servo-driven solutions, this dry powder filling machine represents the pinnacle of pharmaceutical packaging technology.

The Automatic Servo Base Liquid Filling Machine by Harikrushna Machines Pvt. Ltd. (HMPL) delivers high-speed, precise, and clean filling performance for a wide range of liquid products. Its robust structure, adjustable product transmission belt, SERVO-based filling pumps, and intelligent PLC–HMI controls ensure consistent accuracy with minimal wastage. The pneumatic bottle stopping mechanism synchronizes each fill cycle smoothly, while the high/low tank level sensor maintains a continuous product flow. Available in models with 2 to 12 filling heads, this machine achieves outputs of up to 120 bottles per minute, making it an ideal solution for modern, high-efficiency production lines.

The Vial Washing Machine by Harikrushna Machines Pvt. Ltd. is designed to deliver efficient and thorough internal and external washing of vials with minimal mechanical contact, ensuring product safety and container integrity. This model, HMPL-RVW, easily accommodates 2 ml to 100 ml glass and plastic vials with the help of quick change parts for flexible size adjustments. Operating at an impressive speed of up to 400 vials per minute, it provides a continuous, smooth, and contamination-free washing process ideal for pharmaceutical, biotech, and healthcare production environments. This machine ensures clean, reliable, and high-capacity vial preparation while maintaining hygienic operation standards.

HMPL Sterile's Automatic Eye Drop Filling Machine is suitable for filling free flow liquid from 5 ml to 15 ml eye/ ear drop bottles with up to 200 bottles per minute.